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Pop along between 11am and 4pm. Entry is 16 for adults and 9.60 for children. Call (01799) 522842 to find out more.. In an unbiased whole brain approach, we analyzed regionally derived structural MRI estimates of GM and WM volume, cortical thickness and surface area, and also TIV.24, 30 We also investigated brain microstructure using an independent data set of DWI images from the same subjects, from which we computed fractional anisotropy and mean diffusivity as indices of local tissue integrity.31 Gene dosage effects on brain anatomy were tested explicitly over the cohorts of deletion carriers, controls and duplication carriers using differential contrasts and conjunction analyses. Both GM (P and WM volume (P e 05) contribute to the observed effect on TIV (Figures 1c and d). There is no significant correlation between gene dosage and cerebrospinal fluid volume suggesting that there are no compensatory cerebrospinal fluid changes secondary to brain atrophy.

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